Nitric oxide vascular disorders

Radomsid MW, Salas E. (1995b). Platdet regulation and damage in vascular thrombotic and septic disorders. In Role of nitric oxide in sepsis and ARDS. Fink MP, Payen D eds. Springer- Verlag Berlin Hdddberg New Yotk,iq). 138-154. 

Cloricromsn [inn] is a benzopyran derivative, a NITRIC OXIDE SYNTHASE INHIBITOR, coronary VASODILATOR. PLATELET AGGREGATION INHIBITOR and antischaemic. It has possible ANTIINFLAMMATORY / IMMUNOSUPPRESSANT properties, and has been used to treat arterial vascular disorders where there is a... 

ADHD, attention-deficit/hyperactivity disorder AV, atrioventricular BPH, benign prostatic hypertrophy CAD, coronary artery disease CHF, congestive heart failure COPD, chronic obstructive pulmonary disease CV, cardiovascular DA, dopamine Dl, subtype 1 dopamine receptor Epi, epinephrine FFA, free fatty acids 5-HT, serotonin ISA, intrinsic sympathomimetic activity MI, myocardial infarction NE, norepinephrine NO, nitric oxide PVR, peripheral vascular resistance. 

The MPO-catalyzed chlorination of membranes of exogenous microorganisms (bacteria, viruses, parasites, etc.) is a powerful antimicrobial activity generated at the contact of neutrophils with the microbes. However, MPO also contributes to the pathogenesis of several inflammatory and vascular disorders by converting free amino acids to reactive aldehydes.It has been found that nitric oxide (the radical NO ) also plays a central role in these disorders. Activated MPO converts N02 into NO2CI and NO2 , both of which are able to nitrate tyrosine residues. These MPO-mediated nitrations are enhanced by fluxes of nitric oxide. 

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