Nitric oxide in biological systems

Gabr, I., Patel, R.P., Symons, M.C.R., and Wilson, M.T. 1995. Novel reactions of nitric oxide in biological systems. J. Chem. Soc., Chem. Commun. 915-916. 

F. Bedioui, S. Trevin, and J. Devynck, Chemically modified microelectrodes designed for the electrochemical determination of nitric oxide in biological systems. Electroanalysis 8, 1085-1091 (1996). 

M. Tristani-Firouzi, E.G. DeMaster, B.J. Quast, D.P. Nelson, and S.L. Archer, Utility of a nitric oxide electrode for monitoring the administration of nitric oxide in biologic systems. J. Lab. Clin. Med. 131, 281-285 (1998). 

Gow AJ, Thom SR, Brass C, Ischiropou-los H. 1997. Electrochemical detection of nitric oxide in biological systems. Microchem. J. 56 146-54... 

Vanin AF (1998) Dinitrosyl iron complexes and S-nitrosothiols are two possible forms for stabilization and transport of nitric oxide in biological systems. Biochemistry 63 782-793... 

Malinski and Taha reported in 1992 on a very interesting application of an electropolymerized nickel porphyrin film electrode for in situ amperometric detection of nitric oxide in biological systems . The authors coated carbon fibres... 

Data adapted with permission from Vanin A et al. (2000) Redox properties of iron-dithiocarbamates and their nitrosyl derivatives Implications for their use as traps of nitric oxide in biological systems. Biochimica Biophysica Acta 1474 365-377. 

Electrochemical Measurements of Nitric Oxide in Biological Systems... 

The importance of nitric oxide in biological systems was introduced in Chapter 8. Draw the molecular orbital diagram for nitric oxide. (Assume the ordering of molecular orbitals to be like that in O2.)... 

Since its identification as the endothelial derived relaxation factor (EDRF) there has been an explosive growth in the study NO (nitric oxide) in biological systems [38-42]. One of the difficulties associated with its study and determination is the fact that it has a very short lifetime. Thus, methodologies for the determination of NO have been largely indirect There is, however, a Rowing interest in the direct and in-vivo determination of NO. Because of their inherent sensitivity, electrochemical techniques are especially well suited for the development of analytical approaches for NO and the use of microelectrodes can allow, as was recently demonstrated, for in-vivo determinations [9c]. In addition, NO can be oxidized at about +0.80 V (vs SCE) at a platinum electrode (as well as at other electrode materials) although nitrite, ascorbate and other species can seriously interfere with the determination. In addition, in the case of in-vivo determinations, protein adsorption can also present difficidties. However, one can... 

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