Nitric oxide hyperglycemia effect

Modification of human serum albumin by o-glucose impaired its antiapoptotic activity for endothelial cells a 50% loss of activity corresponded to about four fiuctosamine residues per protein molecule. In another study, D-fiuctose-albumin enhanced nitric oxide synthase activity and a consequent NO-dependent apoptosis in vascular endothelial cells. " This effect was also attributed to a possible mechanism of hyperglycemia-induced vasculopathy in diabetic patients. In proximal tubular epithelial cells, however, the effect of co-incubated D-fiuctose-albumin was the... 

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