Nitric acid oxidation polyols

With nitric acid, the polyols may be oxidized to the corresponding dibasic acids. This procedure provides a qualitative identification of galactitol by converting it to insoluble mucic acid, but galactose and galacturonic acid give the same product. See 106). 

Cameron NE, Cotter MA, Hohman TC. Interactions between fatty acid, prostanoid, polyol pathway and nitric oxide mechanisms in the neurovascular deficit of diabetic rats. Diabetologia 1996 39 172-182. 

PLURACOL POLYOL (25322-69-4) Combustible liquid (flash point 390°F/198°C). Incompatible with oxidizers, sulfuric acid, nitric acid, caustics, aliphatic amines, isocyanates, boranes. 

A relationship between polyol pathway activity and reduction in endothelium-dependent relaxation in aorta from chronic STZ-diabetic rats has recently been reported (Cameron and Cotter, 1992). In agreement with several previous studies (Oyama et al., 1986 Kamata et al., 1989), endothelial-dependent relaxation was defective in the diabetic rats but the deficit was prevented by prior treatment with an AR inhibitor. The mechanism underlying the defect has been speculated to be due to decreased production of endothelium-derived relaxing factor (EDRF) or nitric oxide, NO (Hattori et al., 1991). It has been speculated that these vascular abnormalities may lead to diminished blood flow in susceptible tissues and contribute to the development of some diabetic complications. NO is synthesized from the amino-acid L-arginine by a calcium-dependent NO synthase, which requires NADPH as a cofactor. Competition for NADPH from the polyol pathway would take place during times of sustained hyperglycaemia and... 

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