Phenprocoumon Nitrazepam

Also analyzed acebutolol, acetaminophen, alprazolam, amphetamine, atenolol, betaxolol, brotizolam, caffeine, camazepam, captopril, chloroquine, clobazam, clomipramine, cloth-iapine, clotiazepam, cloxazolam, cocaine, codeine, diclofenac, dihydralazine, dihydrocodeine, dihydroergotamine, diphenhydramine, domperidone, doxepin, droperidol, ergota-mine, ethyl loflazepate, fenethylline, fluoxetine, flupentixol, flurazepam, furosemide, gliclazide, hydrochlorothiazide, hydroxyzine, ibuprofen, imipramine, ketazolam, loprazo-1am, lorazepam, lormetazepam, maprotUine, medazepam, mepyramine, methadone, methaqualone, methyldopa, methylphenidate, metoclopramide, metoprolol, mexiletine, mianserin, midazolam, minoxidil, morphine, nadolol, nitrazepam, oxprenolol, papaverine, pentazocine, phenprocoumon, phenylbutazone, pipamperone, piritramide, practolol, pra-zepam, prazosin, promazine, promethazine, propoxyphene, propranolol, prothipendyl, quinine, sotalol, sulpride, thioridazine, trazodone, triazolam, trimipramine, tripelennamine, lyramine, verapeunil, yohimbine... 

The anticoagulant effects of warfarin are not affected by chlo-rdiazepoxide, diazepam, flurazepam, or nitrazepam, or the related hypnotics, eszopiclone, zaleplon, or zolpidem. The effects of phenprocoumon are not affected by nitrazepam or oxazepam, and those of ethyl biscoumacetate are not affected by chlo-rdiazepoxide. An interaction between any oral anticoagulant and a benzodiazepine is unlikely, but there are three unexplained and unconfirmed cases of increased or decreased anticoagulant responses, which were attributed to an interaction. 

In 2 reports by the same researchers, nitrazepam 10 mg at night for 30 days had no effect on steady-state warfarin levels or anticoagulant control in a few patients stabilised on warfarin. In a placebo-controlled study in 22 patients stabilised on phenprocoumon, nitrazepam 5 mg at night for 2 weeks had no effect on thrombotest times. ... 

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See also in sourсe #XX -- [ ]

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