Nitidine antileukemic activity

Avicine and Nitidine. Among many 2,3,8,9-tetrasubstituted alkaloids, nitidine (77) and fagaronine (79) have been shown to possess very potent antileukemic activity, therefore becoming targets for their synthesis 82,83). 

Nitidine (5) was isolated for the first time from Z nitidum [49,50]. Alkalization of the quaternary salts leads to a mixture of 5,6-dihydroniti-dine and 6-oxonitidme [49,50]. The salts are relatively stable as is the pseudocyanide [49]. Avicine (6), first isolated from Z avicennae DC., is also an unstable species [51]. Fagaronine (7), a phenolic QBA of the nitidine type, has been isolated from Fagara xanthoxyloides Lam [52] and exhibits a high antileukemic activity. 

Nitidine and garonine are known as potential anti-tumour, antileukemic, and antiviral agents [9,52,98]. Some synthetic 12-alkoxyderivatives of 2,3,8,9-tetramethoxy QBA are potent in vitro inhibitors of the growth of P388 cells [144]. Nitidine, isolated firom Kenyan Toddalia aculeata Pers. (synonym T. asiatica (L.) Lamk.) has shown antimalarial activity [145]. Nitidine and fagaronine have been foimd to inhibit HTV reverse transcriptase [146]. 

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See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ , ]

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