Nifedipine Antidiabetics

Cyclodextrin-based drug delivery systems The hydrophilic cyclodextrins have been extensively )plied to enhance the oral bioavailabilily of steroids, cardiac glycosides, nonsteroidal anti-inflammatory drugs, barbiturates, antiepileptics, benzodiazepines, antidiabetics, vasodilators, etc. Delayed and prolonged release of diltiazem and molsidormine was achieved by their complexation with CD derivatives, modified release of nifedipine can be achieved by its complexation with 2-HP-P-CD fiirosemide and piretanide (loop diuretics) release can be modified after complexation with DM-P-CD. Prednisolone dosage forms can be optimized also by complex-formation with 2-HP-P-CD. 

Dihydropyridine (DHP) drugs such as nifedipine, nicardipine, amlodipine, and others are effective cardiovascular agents for the treatment of hypertension [63], DHPs have been explored for their calcium charmel activity and are foimd as a constituent in a variety of bioactive compounds which show many biological activities such as vasodilator, bronchodilator, antiatherosclerotic, antitumor, antidiabetic, geroprotec-tive, heptaprotective [64], etc. 

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