Nicotinic acetylcholine receptor chemistry

There are two main families of ligand-gated ion channel proteins that act as ionotropic receptors. One family includes the nicotinic acetylcholine receptor, the GABA-A receptor, the glycine receptor, and a class of serotonin receptor. The other family comprises various types of ionotropic glutamate receptors. Since these various ligand gated ion channels are activated by neurotransmitters, the medicinal chemistry of these proteins is presented in detail in chapter 4. 

R.J. Lind, D.T. Greenhow, J. Blythe, J. Goodchild, E. Hirst, S.J. Dunbar and F.G.P. Earley, Cyanotropanes Novel Chemistry Interacting at the Insect Nicotinic Acetylcholine Receptor in BCPC Conference - Pests Diseases, British Crop Protection Council, 2002, Vol. 1, pp. 145-152. 

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DISCOVERY OF ABT-594 AND RELATED NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS AS ANALGESIC AGENTS MEDICINAL CHEMISTRY AND BIOLOGY... 

Ziebell, M. R., Nirthanan, S., et al. (2004). Identification of binding sites in the nicotinic acetylcholine receptor for [3H]azietomidate, a photoactivatable general anesthetic. The Journal of Biological Chemistry, 279(17), 17640-17649. 

Wonnacott S, Gallagher T (2006) The chemistry and pharmacology of anatoxin-a and related homotropanes with respect to nicotinic acetylcholine receptors. Mar Drugs 4 228-254. doi 10.3390/md403228... 

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Laboratory Blood counts and chemistries, including thyroid tests, were normal. Antibodies to the nicotinic acetylcholine receptor and to striated muscle were negative (the former are typically positive in myasthenia gravis (MG), and the latter would suggest the presence of a thymoma). 

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