Niclocide - Niclosamide

Technical Information Niclocide (R), niclosamide, Miles Laboratories, West Haven, CT, 1981. 

For many years, niclosamide (Niclocide) was widely used to treat infestations of cestodes. Niclosamide is a chlorinated salicylamide that inhibits the production of energy derived from anaerobic metabolism. It may also have adenosine triphosphatase (ATPase) stimulating properties. Inhibition of anaerobic incorporation of inorganic phosphate into ATP is detrimental to the parasite. Niclosamide can uncouple oxidative phosphorylation in mammalian mitochondria, but this action requires dosages that are higher than those commonly used in treating worm infections. 

Oral 100 mg chewable tablets outside the USA, 100 mg/5 mL suspension Metrifonate (trichlorfon, Bilarcil)1 Niclosamide (Niclocide)1 Oxamniquine (Vansil, Mansil)1... 

Niclosamide (Niclocide) used for beef and fish tapeworms PO 2 g, single dose treatment of dwarf tapeworms PO 2 g/d x 1 wk... 

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