Nickel peroxide natural products

The one-electron oxidation of a secondary amine results in the formation of a secondary aminium ion which on deprotonation gives an aminyl radical (Scheme 1). The nature of the final products derived from these intermediates dqiends very much on the structure of the substrate and the reaction conditions. If the amine has a hydrogen atom on the a-carbon atom the major products usually result from deprotonation at this a-position. With aromatic secondary amines, products can result from coupling of the delocalized radicals at a ring carbon atom. The formal dimerization of aminyl radicals shown in Scheme 21 is therefore not often a useful method of preparation of hydrazines. Nickel peroxide has been used to oxidize diphenylamine to tetraphenylhydrazine in moderate yield, and other secondary arylamines also give... 

Dehydrogenation of dihydro derivatives of thiazoies, imidazoles, furanes. In a study directed toward synthesis of a natural product containing a bithiazole group, Hecht et al. examined various reagents for oxidation of the thiazoline 1 to the corresponding thiazole 2. Nickel peroxide was found to be superior to activated MnOa, which effected this conversion in a yield of 65 7o- No other... 

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