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Nickel catalysts Sonogashira reaction

Besides palladium catalysts, nickel was also found to be an effective catalyst for the Sonogashira reaction in aqueous media. Recently, Beletskaya et al. reported a Ni(PPh3)2Cl2/CuI-catalyzed Sonogashira coupling reaction of terminal acetylenes with aryl iodides in aqueous dioxane in high yields (Eq. 4.19).39... [Pg.109]

In 2008 Bhanage s team reported on a copper-catalyzed carbonylative Sonogashira reaction of aryl iodides [68]. In this procedure, copper bis(2,2,6,6-tetra-methyl-3,5-heptanedionate) [Cu(TMHD)2] was used as the catalyst for this transformation and using NEta as a base. Alkynones were produced in good yields (Scheme 5.33). A nickel-catalyzed carbonylation of allyl halides and acetylenes was reported on by Moreto and colleagues [69]. Cyclopentane skeletons were produced in high yields and with controlled stereochemistry. [Pg.112]

Other successful examples of catalysts containing NHC ligands are found in palladium- and nickel-catalyzed carbon-carbon bond formations. The catalyst development with these metals has focused in particular on Heck-type reactions, especially the Mizoroki-Heck reaction itself [Eq. (42)] and various cross coupling reactions [Eq. (43)], e.g., the Suzuki-Miyaura reaction ([M] = and the Kumada-Corriu reaction ([M] = MgBr). " Related reactions like the Sonogashira coupling [Eq. (44)]326-329 Buchwald-... [Pg.42]

An analogous nickel catalyzed coupling was also reported recently, where 3-, and 4-cyanopyridine were coupled with different ethynylzinc derivatives in the presence of a nickel-phosphine catalyst system (7.43.),61 Although this reaction is not a Sonogashira coupling, it constitutes an efficient alternative approach to ethynylpyridines. It is also interesting to... [Pg.154]


See other pages where Nickel catalysts Sonogashira reaction is mentioned: [Pg.46]    [Pg.47]    [Pg.113]    [Pg.324]    [Pg.962]    [Pg.961]    [Pg.706]    [Pg.8]    [Pg.1]    [Pg.25]    [Pg.54]    [Pg.314]    [Pg.20]    [Pg.119]    [Pg.18]    [Pg.879]    [Pg.58]    [Pg.347]    [Pg.120]   
See also in sourсe #XX -- [ Pg.126 ]




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Reaction nickel

Sonogashira reaction

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