Niacin-induced vasodilation

Niacin-induced vasodilation is believed to be mediated by prostaglandins. The mechanism of hepatotoxicity associated with niacin use is unknown. 

Thus GPR109A mediates the niacin-induced antilipolysis effect in adipocytes and vasodilation effect in skin. This discovery represents significant progress in understanding the mechanism of action for niacin, but also poses a challenge to develop a therapeutic agent to separate the lipid and vasodilation effects. 

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