Next Generation of Orthopedic and Dental Implants Nanophase Ceramics

Next Generation of Orthopedic and Dental Implants Nanophase Ceramics 

Traditional materials for orthopedic and dental applications have been selected based on their mechanical properties and ability to remain inert in vivo this selection process has provided materials that satisfied physiological loading conditions but did not duplicate the mechanical, chemical, and architectural properties of bone. Most importantly, to date, failure of conventional orthopedic and dental implant materials is often due to insufficient bonding to juxtaposed bone (that is, insufficient osseointegration). 

Biomaterial scientists and engineers are currently investigating novel formulations and modifications of existing materials that elicit specific, timely, and desirable responses from surrounding cells and tissues to support the osseointegration of the next generation of orthopedic and dental biomaterials (Ratner, 1992). Enhanced deposition of mineralized matrix at the bone-implant interface provides crucial mechanical stability to implants. Proactive orthopedic and dental biomaterials could consist of novel formulations that selectively enhance osteoblast function (such as adhesion, proliferation and formation of calcium-containing mineral) while, at the same time, minimize other cell (such as fibroblast) functions that may decrease implant efficacy (e.g., fibroblast participation in callus formation and fibrous encapsulation of implants in vivo). 

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