New Points of Interest

This section illustrates why a site must constantly be reevaluated based on new information and the rethinking of old information. Residents, stakeholders, and regulators will see specific examples of how to add points of interest (POIs) as new information is developed. 

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Calculating points on a set of PES, and fitting analytic functions to them is a time-consuming process, and must be done for each new system of interest. It is also an impossible task if more than a few (typically 4) degrees of freedom are involved, simply as a consequence of the exponential growth in number of ab initio data points needed to cover the coordinate space. 

In this section, the latest developments and recent publications on the biosynthesis of A9-THC and related cannabinoids as precursors are discussed. Special points of interests are the genetic aspects, enzyme regulation, and the environmental factors that have an influence on the cannabinoid content in the plant. Because of new and innovative developments in biotechnology we will give a short overview of new strategies for cannabinoid production in plant cell cultures and in heterologous organisms. 

A further point of interest is their ready interconversion in solution, which we have studied by variable temperature n.m.r. measurements (8). Reaction of [(n-C5H5)(0C)2W =CR] with polynuclear metal carbonyl species is likely to afford many new heteronuclear cluster compounds containing tungsten. 

Although these polymers are of interest none show outstanding conductivity or serve to illustrate any new point of theory. From the preparative point of view they represent a considerable effort toward the synthesis of new and more highly conducting polymers. 

Another point of interest was the time required to equilibrate the system after changes were made in solvent composition. While the ChromSpher Lipids column had a column volume of ca. 3 ml, an increase in ACN concentration was not noted until the introduction of 7-8 ml of solvent (determined with refractive index detector). The problem of ACN-silver ion interaction and subsequent ACN retention is not new and may be noted in all forms of chromatography employing silver ions in the stationary phase. In the isocratic system, the column was equilibrated with the appropriate solvent mix for at least 0.5 h before sample injection. Since ACN dissolves very slowly into hexane, the ACN-hexane solvent mix was thoroughly stirred for 5 min before use. To obtain reproducible retention times, thorough mixing of the ACN and hexane is essential. 

A new heterocyclic ring system, 5//-pyrazolo[3,4- /]-l, 2,3-thiadiazoles (41), results from a one-pot, two-step reaction of the pyrazolodithiazolium chlorides (29). Sequential treatment of the derivatives (29) with base, sodium dithionite, and sodium nitrite followed by acidification afforded (41) (Scheme 3). For substrates (29a,b) potassium hydroxide was chosen, whilst for (29c,d) sodium bicarbonate was found to be superior. In the latter cases, potassium hydroxide caused appreciable hydrolysis of the ester substituent. A further point of interest is the significant quantity of disulfide (43) which can form on reaction of 6-carboethoxy-5-methylpyrazolodithiazolium chloride (29c). This, however, need not represent a problem since compound (43) can be converted in situ or isolated and converted to the desired product (41c) in good yield (Scheme 4) <84JOCl224>. 

Wasielewski stressed the importance of avoiding groups in the building block that could interfere with those positions. His team developed a new functionalization strategy for the 20 positions of chlorophyll so that there is a hook to attach other species and to use without getting in the way of self-assembly points of interest. 

Over the past several years, there has been a renewed interest in thermodynamics and many scientists have considered it from new points of view [1-8]. Thermodynamics is a universal effective theory [9]. It does not depend on the details of underlying dynamics. The first law is the conservation of energy. The second law is the nonnegativeness of excess heat production. It is valid for wide classes of Markov processes in which systems approach to the Boltzmann equilibrium distribution. 

Other major points of interest in clinical trials are hyperinsulinaemia and insulin resistance as a common denominator of the metabolic syndrome, hyperinsulinaemia as an independent predictor of coronary heart disease, and the efficacy of new insulin analogues. 

In coordination chemistry, the most likely reason to be concerned with the growth of crystals is in order to obtain a crystal structure by either X-ray or neutron diffraction from a single crystal. Major points of interest are the quality and size of crystals for this purpose. The size requirements have become less severe in recent years, because of the development of new diffraction techniques, particularly the widespread introduction of area detectors and the use of more powerful sources of X rays (including synchrotron radiation) and neutrons, and it is also possible to obtain structural results from poorer quality crystals than was formerly the case. However, the main factor influencing the quality and precision of a crystal structure is usually the quality of the crystal from which the data are obtained, and a low-precision structure, although of some use, is restricted in value, may not provide the desired information, and is likely to be unpublishable. 

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