New Nebulizer Technology

University of Bradford Bradford, West Yorkshire, Engiand 

Marcel Dekker, Inc. 270 Madison Avenue. New York, New York 10016 

However, a pMDI without spacer or a DPI with a poor inhalation maneuver is an equally inefficient drug aerosol delivery device. Further, a greater proportion of drag aerosol from pMDIs and DPIs is usually deposited in the mouth, throat, and upper respiratory tract, where the drug is of no therapeutic consequence and may contribute to unwanted local or systemic side effects. 

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For the purposes of this chapter, new nebulizer technologies include technology developed and introduced after 1990 that further, are regarded as fundamentally different from traditional nebulizers. New nebulizer technology introduced in this chapter is presented as four classes ... 

Examples of recent developments in new nebulizer technologies and significant new modifications to traditional nebulizer technologies are considered in turn below. 

C. New Nebulizer Technology Developed for Specific Drug Applications Respimat and AERx... 

Two new nebulizer technologies have only recently been introduced in principle their specific system design and application have not yet been publicized. Each utilizes distinctly different new nebulizer technology. Each would be expected to offer exciting new applications in nebulized aerosol therapy, though this will depend in part on how the technology is fiilly developed in collaboration with industrial partners. 

Table 1 Summary of Relative Designed Aerosol Output Characteristics of New Nebulizer Technologies Compared with a Traditional Nebulizer and a Typical pMDI...

Nebulized drug delivery is possibly the most confused area of clinical practice, largely as a result of little or no regulatory control. New nebulizer technology offers greater convenience and portability and a significant increase in aerosol dose delivery. On one hand, this new, more efficient technology offers... 

Descriptions of new nebulizer technologies included in this chaptCT have variable lengths. This may give the reader the false impression that some technologies were more favorably presented than others. This was not intended, as it was more the scarcity of published data relating to some new nebulizer technology that proved limiting. 

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