New glucocerebrosides

A new glucocerebroside, linckiacerebroside A (10) (Fig. 6), together with nearly homogeneous cerebrosides containing phytosphingosine-type long-chain bases and 2-hydroxy fatty acids, was isolated from the starfish Linckia laevigata [46]. 

Chemical examination of the North Pacific starfish Asterias amurensis led to the isolation of a new glucocerebroside, asteracerebroside G (11) (Fig. 7),... 

Guided by the brine shrimp lethality assay, eight new glucocerebrosides (47-54) were obtained from the sponge Haliclona (Reniera) sp, (Fig, 17) [62], A novel feature of these cerebrosides was the presence of unprecedent... 

FIGURE 17 New glucocerebrosides (47-67) from the sponge Haliclona (Reniera) sp. 

Kisa, P., Yamada, K., Kaneko, M., Inagaki, M., and Higuchi, R. (2005) Constituents of Holothuroidea. 14. Isolation and structure of new glucocerebroside molecular species from the sea cucumber Stichopus japonicus. Chem. Pharm. Bull., 53, 382-386. 

Chemical investigation of the feather star Comanthus japonica yielded two new p-glucocerebrosides (43 and 44) and two known compounds. One of the new cerebrosides (39) is unique in that it is the first type of glucosylcer-amide isolated from an echinoderm composed of a ph3 tosphingosine base and a nonhydroxylated fatty acyl moiety (Fig. 15) [58]. 

Two new sphingosine-type glucocerebrosides, sarcoehrenosides A (69) and B (70), were isolated from the alcyonacean soft coral S. ehrenbergi (Fig. 19) [28]. Compound A differs from previously known marine cerebrosides in that it possesses a rare a-D-glucose moiety. Both compounds, together with four known glucocerebrosides isolated from the same coral, were evaluated for antimicrobial activity against a small panel of five bacterial strains. None of the compounds exhibited antibacterial activity at a concentration of 100 pg/disk. 

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