New Concepts in Medicinal Chemistry of Bisindole Alkaloids

New Concepts in Medicinal Chemistry of Bisindole Alkaloids 

In so far as the goal of structure modification programs is the discovery of new antineoplastic agents with improved therapeutic selectivity and an 

A third conjugation strategy was developed in which carbohydrate resi- 

Release of 4-Deacetylvinblastine Hydrazide from 4-Deacetylvinblastine Hydrazine-KS1/4S2 Conjugate as a Function OF Temperature and pH 

The rate of hydrolysis is slow relative to the rate of attachment to tumor, however, and effectively delivers drug to tumor tissue as evidenced by the extreme biological potency of conjugates of this type (Table XVI). 

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VIII. New Concepts in Medicinal Chemistry of Bisindole Alkaloids... 

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