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Simvastatin 4- Nevirapine

CYP3A4 activity, significantly decreasing plasma concentrations and the pharmacologic effect of a number of agents, including alprazolam, amitriptyline, cyclosporine, indinavir, methadone, nevirapine, simvastatin, tacrolimus, and oral contraceptives (69-77). [Pg.237]

Simvastatin increased oral clearance of nevirapine with... [Pg.1395]

GR is a 55-year-old HIV positive man currently receiving ritonavir/lopinavir, nevirapine, and lamivudine. You would like to start simvastatin to decrease his triglycerides. Which of his ARVs will interact with simvastatin ... [Pg.138]

E Simvastatin is metabolized by CYP3A4. Nevirapine is an inducer of CYP3A4, whereas lopinavir and ritonavir are inhibitors of CYP3A4. Thus, the effect of these two drugs on simvastatin levels is unpredictable. Lamivudine is not metabolized by the CYP450 system and will not affect simvastatin levels. [Pg.176]

Delavirdine is expected to raise the levels of atorvastatin, simvastatin and lovastatin. This expectation is supported by a case of rhabdomyolysis, which developed in a patient taking atorvastatin and delavirdine. Efavirenz (and possibly nevirapine) lower the levels of atorvastatin, simvastatin, and pravastatin. [Pg.1106]

See other pages where Simvastatin 4- Nevirapine is mentioned: [Pg.296]    [Pg.1395]    [Pg.296]    [Pg.496]    [Pg.296]    [Pg.1107]    [Pg.36]   
See also in sourсe #XX -- [ Pg.1106 ]



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