Norethisterone Nevirapine

NEVIRAPINE PROGESTOGENS- NORETHISTERONE 1 efficacy of contraceptives, with risk of contraceptive failure Uncertain Avoid co-administration recommend alternative non-hormonal contraceptives - barrier methods are necessary to prevent transmission of infection... 

Nevirapine modestly reduces ethinylestradiol and norethisterone ieveis. Efavirenz and delavirdine increased the levels of ethinylestradiol, while ethinylestradiol had no effect on efavirenz lev-eis. Potentiai contraceptive failures have been reported in two women taking efavirenz. 

A study in 10 HIV-positive women found that nevirapine 200 mg once daily for 2 weeks then twice daily for a further 2 weeks decreased the median AUC and elimination half-life of ethinylestradiol by 29% and 31%, respectively, and decreased the median AUC of norethisterone by 19%. The women received two single doses ofa combined oral contraceptive (ethinylestradiol/norethisterone 35 micrograms/1 mg) 2 days before the nevirapine and on the last day of the nevirapine. Nevirapine was added to established antiretroviral therMy (commonly 3 drugs), which had been unchanged for at least 4 weeks. A retrospective study identified 22 women who were prescribed oral eontraceptives and also reeeived an NNRTl. None of the 6 women taking nevirapine experienced contraceptive failure. However, medication adherence could not be confirmed. ... 

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See also in sourсe #XX -- [ , ]

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