Neutral solutes, ionic liquids, solute-solvent interactions

The popularity of reversed-phase liquid chromatography (RPC) is easily explained by its unmatched simplicity, versatility and scope [15,22,50,52,71,149,288-290]. Neutral and ionic solutes can be separated simultaneously and the rapid equilibration of the stationary phase with changes in mobile phase composition allows gradient elution techniques to be used routinely. Secondary chemical equilibria, such as ion suppression, ion-pair formation, metal complexatlon, and micelle formation are easily exploited in RPC to optimize separation selectivity and to augment changes availaple from varying the mobile phase solvent composition. Retention in RPC, at least in the accepted ideal sense, occurs by non-specific hydrophobic interactions of the solute with the... 

The solvation of neutral species in ionic liquids is distinct from those of charged ions because the solute-solvent interactions can be complex and the presence of neutral solutes can affect the structure of the solution. In COIL-2, several groups addressed solvation and its dynamics in ionic liquid media. Rebelo and collaborators [18] associated molecular simulation studies and... 

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