Neutral loss filter metabolite detection using

Zhu, M., Zhang, H., Yao, M., Zhang, D., Ray, K., and Skiles, G. L. (2004). Detection of metabolites in plasma and urine using a high resolution LC/MS-based mass defect filter approach Comparison with precursor ion and neutral loss scan analyses. Drug Metab. Rev. 36 (Suppl. 1) 43. 

Several MS acquisition and data processing strategies are used for detection and structure elucidation of metabolites. The common metabolite detection strategies are summarized in Section 9.2.1, which include full MS scan, constant neutral loss, parent ion scan, multiple reactions monitoring, and mass defect filtering. The structure elucidation strategies feature product ion scan, multistage scan, and accurate mass measurement, which are reviewed in Section 9.2.2. 

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