Neurotransmission axonal conduction

Discussion of vulnerability of the axon and its terminal to toxicants must be based on an appreciation of specialized aspects of the metabolism of the neuron. This cell type has been discussed in the chapter dealing with the CNS. The concepts of chemically mediated neurotransmission, second messenger systems, specialized ion channels, and conduction of waves of depolarization with consequent high demand for energy to restore Na+ and K+ ion gradients are applicable to the PNS as well as the CNS. Of particular relevance is the fact that the neuromuscular junction is cholin-... 

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