Neurotoxicity tetanus toxin

Schiavo G, Papini E, Genna G, Montecucco C (1990) An intact interchain disulfide bond is required for the neurotoxicity of tetanus toxin. Infect Immun 58 4136 11 Scott AB, Magoon EH, McNeer KW, Stager DR (1989) Botulinum treatment of strabismus in children. Trans Am Ophthalmol Soc 87 174-180 discussion 180 1 Scott D (1997) Phospholipase A2 structure and catalytic properties. In Kini R (ed) Venom phospholipase A2 enzymes structure, function and mechanism. John Wiley Sons, Chichester, p 97-128. 

Westerlund B, Nordlund P, Uhlin U, Eaker D, Eklund H (1992) The three-dimensional structure of notexin, a presynaptic neurotoxic phospholipase A2 at 2.0 A resolution. FEBS Lett 301 159-64 Williamson LC, Neale EA (1994) Bafilomycin Al inhibits the action of tetanus toxin in spinal cord neurons in cell culture. J Neurochem 63 2342-5... 

Schiavo G, Papini E, Genna G, Montecucco C (1990) An intact interchain disulfide bond is required for the neurotoxicity of tetanus toxin. In Infect. Immun. 58 4136-41... 

The seven types of botulinum toxin " and the tetanus toxin " are the most neurotoxic substances known. Only 10 molecules are sufficient to kill a mouse. Both toxins are zinc proteases, which block presynaptic transmitter release by cleaving specific synaptic vesicles proteins (see p. 1780 and Fig. 

Facchiano, F. and Luini, A., 1992, Tetanus toxin potentially stimulates tissue transglutaminase. A possible mechanism of neurotoxicity. J. Biol. Chem. 261 13267-13271. 

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