Neurotoxicants ethanol

Of critical concern is the possibility that developmental exposure may result in an acceleration of age-related decline in function. Animal studies have demonstrated that developmental exposure to neurotoxicants such as methylmercury, methylazoxymethanol, and ethanol may cause few or no neurotoxic effects in young animals, but marked effects in ageing animals. Investigations of effects in ageing animals are not included in regulatory guidelines. 

The definition of neurotoxicity also indicates a potential difference between the developing and the mature nervous system, to underscore the fact that developmental neurotoxicity is an important aspect of neurotoxicology. Most known human neurotoxicants are indeed developmental neurotoxicants.4 In most, but not all cases, the developing nervous system is more sensitive to adverse effects than the adult nervous system, as indicated, for example, by the most deleterious effects of ethanol, methylmercury, or lead when exposure occurs in utero or during childhood. Furthermore, the blood-brain barrier (BBB), which protects the mature nervous system from the entry of a number of substances, appears to be poorly developed at birth and during the first few years of life.6... 

Very many chemicals are recognized teratogens in animals a significantly smaller subset of these is known or suspected to be developmental neurotoxicants in humans. Some of the more significant of the latter group include ethanol, which causes a constellation of effects ranging from fetal alcohol syndrome to alcohol-related neurodevelopmental disorder maternal smoking of tobacco (fetal tobacco syndrome) excess vitamins A and D heavy metals, particularly... 

Carcinogens Organ toxicants Neurotoxicants Ethylene oxide, Cr(IV), vinyl chloride, formaldehyde, arsenic, benzidine Hg, ethanol, beryUium, benzene, carbon tetrachloride, chloroform, arsenic Methylmercury, carbon disulfide, hexane, acrylamide, lead, nicotine, arsenic... 

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