Neuronal Injury During HIV-1 CNS Infection

It is now widely accepted that in the absence of viral infection of neurons or maCTOglia, indirect mechanisms play a major role in HAD neuronal dysfnnction and death. Mnltiple studies per- 

How a relatively small number of infected MP localized in particular areas of the brain can lead to widespread neuronal injury is also unclear. One possibility is that interactions between immune competent MP and astrocytes lead to an amplifica- 

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