Neuromuscular blocking drugs alcuronium

Trimetaphan can increase the effects of suxamethonium (succi-nylcholine), which may result in prolonged apnoea. This may possibly occur with other neuromuscular blocking drugs, such as alcuronium. 

IgE antibodies in serum from a patient who experienced anaphylaxis to alcuronium. Serum is the same as used in inhibitions with neuromuscular blocking drugs—see results Table 7.3... 

Fig. 7.10 Concentration-dependent inhibition of binding of IgE antibodies specific for tertiary and quaternary methyl (mainly) and ethyl eunino groups by neuromuscular blocking drugs. Side-by-side quantitative comparisons of inhibitory potencies of rocuronium and alcuronium with six other neuromuscular blocking drugs. Refer to Table 7.11 for the precise quantitative relationships. The dashed line indicates 50 % inhibition. From Pham NH et al. Studies on the mechanism of multiple drug allergies. Structural basis of drug recognition. J Immunoassay Immunochem. 2001 22 47. Reprinted with permission from Taylor Francis...

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