Neuromuscular blockade muscular effects

It exerts a weak and feeble neuromuscular blocking activity which fails to produce signifieant muscle relaxation except imder deep ether anaesthesia. It has been found to potentiate the neuromuscular blockade caused by tubocurarine and to antagonize the action of decamethonium. Paradoxically, it has been used successfully to prolong and potentiate the relaxant effects of suxamethonium chloride. Besides, it has also been reported to decrease suxamethonium-induced muscular fasciculations. 

Succinylcholine, a depolarizing neuromuscular blocking agent (0.3 to 1.1 mg/kg IV over 10 to 30 seconds), is used to induce skeletal muscle relaxation to facilitate intubation, ventilation, or orthopedic manipulations and to lessen muscular contraction in convulsions induced by physicians. A peripheral nerve stimulator may be used to monitor effects and degree of blockade. 

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