Neuroleptic malignant syndrome paliperidone

Neuroleptic malignant syndrome is characterised by hyperthermia, severe muscle rigidity, autonomic dysfunction and altered mental state. A study of 24 patients who had received a variety of antipsychotics (chlorpromazine, zotepine, paliperidone, bromperidol, supliride, risperidone, thioridazine, olanzapine, fluphenazine, haloperidol, levoproma-zine) demonstrated a temporal relationship of muscle rigidity and elevated creatine kinase to fever [46 ]. 

Nervous system A case of neuroleptic malignant syndrome attributed to paliperidone is reported [194 ]. 

A 22-year-old male on amisulpride and recently withdrawn from clozapine developed neuroleptic malignant syndrome 10 days after the addition of oral paliperidone. 

Ozdemir A, Aksoy-Poyraz C, Kilig-Yener E. Possible paliperidone-induced neuroleptic malignant syndrome a case report. J Neuropsychiatry CHn Neurosci 2012 24(3) E22. ... 

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