Neuroimaging positron emission tomography

Wolf AP, Fowler JS. Positron emission tomography. Biomedical research and clinical application. Neuroimaging Clin N Am 1995 5 87-101. 

Neuroimaging techniques assessing cerebral blood flow (CBF] and cerebral metabolic rate provide powerful windows onto the effects of ECT. Nobler et al. [1994] assessed cortical CBE using the planar xenon-133 inhalation technique in 54 patients. The patients were studied just before and 50 minutes after the sixth ECT treatment. At this acute time point, unilateral ECT led to postictal reductions of CBF in the stimulated hemisphere, whereas bilateral ECT led to symmetric anterior frontal CBE reductions. Regardless of electrode placement and stimulus intensity, patients who went on to respond to a course of ECT manifested anterior frontal CBE reductions in this acute postictal period, whereas nonresponders failed to show CBF reductions. Such frontal CBF reductions may reflect functional neural inhibition and may index anticonvulsant properties of ECT. A predictive discriminant function analysis revealed that the CBF changes were sufficiently robust to correctly classify both responders (68% accuracy] and nonresponders (85% accuracy]. More powerful measures of CBF and/or cerebral metabolic rate, as can be obtained with positron-emission tomography, may provide even more sensitive markers of optimal ECT administration. 

Maquet P (2000) Functional neuroimaging of normal human sleep by positron emission tomography. J Sleep Res 9 207-231... 

Del Parigi, A., J. F. Gautier, K. Chen, A. D. Salbe, E. Ravussin, E. Reiman, et al. (2002). Neuroimaging and obesity mapping the brain responses to hunger and satiation in humans using positron emission tomography. Ann N Y Acad Sci 967 389-97. 

Hougland MT, Gao Y, Herman L, Ng CK, Lei Z, El-Mallakh RS. Positron emission tomography with fluorodeoxyglucose-F18 in an animal model of mania. Psychiatry Res Neuroimaging 2008 164(2) 166-71. 

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