Neuroexcitatory activity

Quisqualic acid - has neuroexcitatory activity (stimulant of glutamic acid receptor)... 

Fig. 13. Position-dependent steric effect on the neuroexcitatory activity of substituted benzyl (lR)-trans-chrysanthema-tes 77) (reproduced with permission from Academic Press, Inc.)...

De Lecea L, Kilduff TS, Peyron C, Gao X-B, Foye PE, Danielson PE, Fukuhara C, Battenberg ELF, Gautvik VT, Barlett FS et al. (1998) The hypocretins hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci USA 95 322-327... 

Of the naturally occurring kainoids, the most potent neuroexcitatory activity has been observed for the acromelic acids, and hence, much synthetic activity has been undertaken in this area. Synthetic studies have been reported, not only on the naturally occurring derivatives 5-9, but also on modified derivatives containing a number of differing aromatic substituents in the C-4 position. 

Kainic acid 327 exhibits an array of biological properties, including insecticidal, anti-thelmic, and neuroexcitatory activity. One of the challenging aspects to the synthesis of... 

Ibotenic acid is a potent neurologic amino acid. It exhibits neuroexcitatory activity and causes sedative actions on spinal neurons. High doses can cause sleep, hallucinations, distorted perceptions, and nausea. In humans the symptoms above may be manifested from ingestion of 6-8 mg of ibotenic acid. 

---