Neurodegenerative diseases calcium

Carmignoto G, Pasti L, Pozzan T (1998) On the role of voltage-dependent calcium channels in calcium signaling of astrocytes in situ. J Neurosci 18 4637-4645 Cartier L, Hartley O, Dubois-Dauphin M, Krause KH (2005) Chemokine receptors in the central nervous system role in brain inflammation and neurodegenerative diseases. Brain Res Brain Res Rev 48 16 2... 

Kwak S., and Weiss J.H. 2006 Calcium-permeable AMPA channels in neurodegenerative disease and ischemia. Curr Opin Neurobiol 16, 281-287. 

For a recent review of mitochondrial calcium function and dysfunction in neurodegenerative diseases (including HD) see Nicholls (2009). 

It has been suggested that perturbed calcium regulation plays a role in age-related neurodegenerative diseases. According to this hypothesis, based on very little and controversial evidence, disrupted calcium homeostasis is involved in both normal and pathological ageing. 

Amyloid pore An oligomer of amyloid proteins that forms a channel, generally permeable to calcium ions, in the plasma membrane of brain cells in patients with neurodegenerative diseases. Pore oligomers are considered as the more toxic forms of amyloid proteins. 

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