Neurobiology of mood disorders

Bunney WE, Garland BL Dthium and its possible modes of action, in Neurobiology of Mood Disorders. Edited by Post RM, Ballenger J. Baltimore, MD, Williams Wilkins, 1984, pp 731-743... 

Post RM, Ballenger JC, Hare TA, et al Cerebrospinal fluid GABA in normals and patients with affective disorders. Brain Res Bull 5 (suppl 2 755-759, 1980 Post RM, Uhde TW, Ballenger JC, et al Prophylactic efficacy of carbamazepine in manic-depressive illness. Am J Psychiatry 140 1602-1604, 1983 Post RM, Ballenger JC, Uhde TW, et al Efficacy of carbamazepine in manic-depressive illness implications for underlying mechanisms, in Neurobiology of Mood Disorders. Edited by Post RM, Ballenger JC. Baltimore, MD, Williams Wilkins, 1984, pp 777-816... 

Gillin JC, Sitaram N, Wehr T, Duncan WC, Post RM, Murphy DL, Mendelson UB, Wyatt RJ, Bunney WE (1984) Sleep and affective illness. In RM Post, JC Ballenger (eds) Neurobiology of Mood Disorder. Williams Wilkins, Baltimore, London, 157— 188... 

Drevets WC, Krishnan KR. Neuroimaging studies of mood disorders in Neurobiology of Mental Illness (Charney DS, Nestler EJ, Bunney BS, Eds) Oxford University Press, New York 1999, pp 394-418... 

Heim, C. and Nemeroff, C. B. The role of childhood trauma in the neurobiology of mood and anxiety disorders preclinical and clinical studies. Biol. Psych. 49 1023-1039, 2001. 

Duman, R.S. (1999) The neurochemistry of mood disorders preclin-ical studies. In Charney, D.S., Nestler, E.J., and Bunney, B.S., eds. Neurobiology of Mental Illness, New York Oxford University Press, (pp. 333-347. 

Bipolar disorder is characterized by episodes of mania or hypomania, which include hyperactivity, decreased need for sleep, and a euphoric or irritable mood. Additionally, persons with bipolar disorder may have episodes of depression similar to those seen in major depressive disorder. The lifetime prevalence of severe bipolar disorder is about 1% and 3-5% if milder cases are included, afflicting men and women equally. Both bipolar disorder and major depressive disorder tend to be episodic, and in the periods of time between episodes, persons may experience few or no symptoms. The etiology of bipolar disorder is predominately genetic, with a 70% concordance in monozygotic twins. The neurobiology of bipolar disorder is less well understood, and few animal models have been developed. Treatment of bipolar disorder usually involves mood stabilizer medications, including lithium, and the anticonvulsants valproate and carbamazepine. At times, antidepressant and antipsychotic medications are also used. 

Brevets W, Gadde K, Krishnan K. Neuroimaging studies of mood disorders. In Neurobiology of Mental Illness (Chamey D, Nestler E, Bunney B, eds) Oxford Oxford University Press, 1999 pp 394 18... 

Volienweider FX, Kometer M (2010) The neurobiology of psychedelic drugs implications for the treatment of mood disorders. Nat Rev Neurosci 11(9) 642-651. doi 10.1038/nm2884... 

CHAPTER 55 Neurobiology of Severe Mood and Anxiety Disorders... 

Thase, M. E. Mood disorders neurobiology. In Kaplan Sadock s Comprehensive Textbook of Psychiatry. Ed. Sadock, V. A. Philadelphia Lippincott Williams Wilkins, 2000, ppl318-1328. 

Mann, J. J. and Arango, V. Abnormalities of brain structure and function in mood disorders. In Neurobiology of Mental Illness. Ed. Bunney, B. S. New York Oxford University Press,... 

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