Neurobehavioral teratology

Oose-effect relations in neurobehavioral teratology may be complex. For instance, high doses of naloxone may stimulate certain aspects of development, while lower doses have the opposite effect (see below). A prenatal dose of 10 mg/kg methadoneresulted in a larger increase in activity of rats on postnatal days 17 and 22 than a dose of 15 mg/kg (ref. 49). This type of dose-effect relations is very common in psychopharmacology, and probably also in neurobehavioral toxicology. Careful choice of dose range is necessary since ineffectiveness of a certain dose level does not always mean that all lower doses can be assumed to have no effect. 

S.J. Wallace, Studies on the effects of anticonvulsant drugs on the developing human brain, in J. Yanai (Ed.), Neurobehavioral Teratology, Elsevier, Amsterdam, 1984, pp. 133-151. 

Adams J Lammer EJ (1993) Neurobehavioral teratology of isotretinoin. Reprod Toxicol, 7(2) 175-177. 

Spear, I P, and File, S. R, (1996). Methodological considerations in neurobehavioral teratology, Pharmacol. Biochem. Rehav. 55,455 57. 

Legrand, J., 1984, Effects of thyroid hormones on central nervous system development, in "Neurobehavioral Teratology , J. Yanai, ed., Elsevier, Amsterdam, p 331. 

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