Neuroanatomical Effects of Lead

Histological analysis reveals a proliferation of astroglial cells in animals exposed to high Pb during development. Histological 

Examination of the developing capillaiy system in high Pb-exposed animals revealed aberrations in the developing capillaiy buds, which were either dilated or lacked apical processes. Electron microscopic examination has revealed capillaiy damage, with vessel walls containing numerous varicosities, the fusion of membranes periodically interrupted, hypertrophied capillaries and endothelial cells, and a few necrotic endothelieil cefis. Lead appears to be concentrated, at least initially, in bredn capillaries in animals exposed to Pb developmentaUy and is localized in the cytoplasm of the capillaiy endothelium cells eifter an intraperitoneal (ip) injection of ra oactive Pb.  

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