Neuroactive agents

Commissaris, R. L., Semeyn, D. R., Moore, K. E., and Rech, R. H. (1980) The effects of 2,5-dimethoxy-4-methylamphetamine (DOM) on operant behavior Interactions with other neuroactive agents. Commun. Psychopharmacol., 4 393-404. 

Neuroactive agents and neuropeptides (brain-targeted delivery) [266] ... 

Table 15.2 provides just a few examples of different neuroactive agents and their mechanism of action. Caffeine, the most widely consumed stimulant drug in the world, works by affecting the adenosine receptor. Adenosine is a naturally occurring depressant, so caffeine works by blocking the depressive actions of adenosine, causing stimulation. 

The home, workplace, and general environment each represent unique places of possible exposure to neuroactive agents (Table 15.5). The home contains a range of compounds that affect the nervous system caffeine in coffee and tea, alcohol, medicines, pesticides, cleaning agents, paints, and solvents to name just a few. Compounds such a lead or pesticides can be carried into the home on shoes or bare... 

Veniafaxine is an antidepressant and, like many neuroactive agents, it is an amino-alcohol, In this case, the two functional groups are 1,3-related, so we aim to use a 1,3-diO disconnection, Usually,... 

Aminobutyramide of /V-glucosyl amine, (III), prepared by Miller (4) was effective as a blood-brain barrier using conjugate for delivery of the neuroactive agents such as serotonin, dopamine, and enkephalin. 

One of the most convincing species differences in the susceptibility of the GABA system to neuroactive agents is that avermectins are more toxic to insects and nematodes than to mammals (43). 

The neuroactive agents from widow spiders are called a-latrotoxins they appear to form trans-membrane channels and usually have high molecular weights ( 130,000). They cause massive release of neurotransmitters as they stimulate fusion of the S maptic vesicles (which contain neurotransmitters) with the pre-synaptic membrane. The Australian red back spider often bites people who are in bed or asleep and the venom has a long-term effect, with patients recovering partially and then collapsing with further pain, numbness of an affected limb and even paralysis, still being affected two months later. Studies have shown that... 

Ci8H25N50,6S2 631.551 Isol. from the funnel-web spider Hololena curta. Neuroactive agent. 

The barbiturate structure resembles that of hydantoins and dialkyl acetyl urea derivatives which are also neuroactive agents (Fig. 4.8). It is clear that the dialkyl substitution at position 5 of barbiturates is essential for their pharmacological activity. Also, if one or two hydrogens are left at position 5 of the barbiturate, the barbiturate will be converted to the trihydroxy pyrimidine derivative, as discussed earlier. 

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