Neurexins alternative splicing

Neurexins a protein kinase. A component of active zones that interact with RIM, syntaxin and other proteins. Cell surface proteins with more than 1,000 isoforms generated by alternative splicing from three genes. Neurexins include one of the receptors for aratrotoxin and may function in cell-cell recognition between neurons. 

Ullrich B, Ushkaryov YA, Siidhof TC (1995) Cartography of neurexins more than 1000 isoforms generated by alternative splicing and expressed in distinct subsets of neurons. Neuron 14 497-507... 

Like neurexins, the NL extracellular domain contains sites for alternative splicing, splice site A and B (SSA and SSB) (Ichtchenko et al., 1995 Ichtchenko et al, 1996). While an alternative splice insert is found in SSA for all neuroligins, the SSB insert seems to be specific for NLl (Comoletti et al., 2006). 

Role of Alternative Splicing in Neurexin/Neuroligin Interaction... 

In both cases alternative splicing not only increases the diversity but also regulates binding between neuroligins and neurexins (Fig. 2). Indeed the neurexin SS4 insert seems to modulate binding to neuroligins, whereas the neuroligin SSB insert strictly... 

Comoletti, D, Elynn, RE, Boucard, AA, Demeler, B, Schirf, V, Shi, J, Jennings, LL, Newlin, HR, Sudhof, TC and Taylor, P (2006) Gene selection, alternative splicing, and post-translational processing regulate neuroligin selectivity for beta-neurexins. Biochemistry 45 12816-12827. 

Ichtchenko, K, Nguyen, T and Sudhof, TC (1996) Structures, alternative splicing, and neurexin binding of multiple neuroligins. J Biol Chem 271 2676-2682. 

Shen, KC, Kuczynska, DA, Wu, IJ, Murray, BH, Sheclder, LR and Rudenko, G (2008) Regulation of neurexin Ibeta tertiary structure and ligand binding through alternative splicing. Structure 16 422-431. 

Tabuchi, K and Sudhof, TC (2002) Structure and evolution of neurexin genes insight into the mechamsm of alternative splicing. Genomics 79 849-859. 

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