Netherlands, proficiency-testing

False-positive results with bDNA have been observed with proficiency testing specimens for HTV-1 in the College of American Pathologists HIV-1 viral load survey and HCV in the viral quality control program administered by the Netherlands Red Cross. The reason for the false-positive results with these proficiency testing specimens is not known but may be sample matrix effects. The extent to which this problem occurs with clinical samples has not been determined. However, both the HIV-1 and HCV bDNA assays were designed to have a false-positive rate of 5%. 

Chemical Proficiency Test No. Matrix China Czech Republic Finland France Germany Korea Netherlands Poland g 1 [I, J I Pi 8 1 00 Switzerland United Kingdom United States of America Belgium India 1 India 2 India 3 Romania Russian Federation 2 Singapore South Africa... 

We acknowledge financial support from the Sixth Framework Programme of the European Union (Contract SSPI-CT-2003-502492 http //www.swift-wfd.com). We also thank Nel Frijns and the RIZA monitoring team in Eijsden (The Netherlands), the local Environmental Agency (in the Aller) for permission to work. Finally, we thank all the partners in the SWIFT-WFD consortium who carried out reference measurements, prepared the reference materials, participated in the proficiency testing and in field studies. 

Starink R J Visser R G Audier M, Results of Proficiency Test. Phthalates in PVC. Institute for Interlaboratory Studies, Dordrecht, the Netherlands, April 2002. 

It has been found in the Netherlands by proficiency testing that the average content of most pharmacy preparations lie between 95 % and 105 % of the stated content. So when accepting a content limit of 90-110 %, the product will be released without further consideration if an assay result is between 95 % and 105 %. Trends in results (up or down) should be investigated as part of product quality reviews. 

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