Nephron, mammalian

At least three types of ATP driven H+ pumps may be potentially involved in the regulation of pHi. These are (a) an electrogenic H+ translocating ATPase found in the mammalian distal nephron (b) an electroneutral K+-H+ exchange ATPase that is responsible for acid secretion by gastric cells and (c) a vacuolar H+-ATPase which is responsible for the low pH of endocytic vesicles. The vacuolar H+-ATPase can be inhibited by the macrolide antibiotic bafilomycin Al. The gastric K+-H+-ATPase is inhibited by antiulcer drugs such as omeprazole. 

Horster M. Primary culture of mammalian nephron epithella requirements for cell outgrowth and proliferation from defined explanted nephron segments. PfIugersArch 382 209-215,1979. 

Morel F. Sites of hormone action In the mammalian nephron. Am J Physiol 240 FI 59-164,1981. 

Jacobson, H. R. (1981). Functional segmentation of the mammalian nephron. Am. J. Ph/siol. 241, F203-F218. 

Tumlin, J. A. (1997). Expression and function of calcineurin in the mammalian nephron Physiological roles, receptor signaling, and ion transport. Am. J. Kidney Dis. 30, 884-895. 

The proximal and distal convoluted tubules of tliese nephrons reach the surface of the cortex. The pars recta of proximal tubules is not accessible. Progress in the micropuncture field was slow because a very sensitive method for the determination of urate was needed, the volume of tubular fluid collected being small (0.1 //liter) and the plasma urate concentration being low (table 1). Furthermore, all mammalian species have uricase activity... 

Kobayashi A, Valerius MT, Mugford JW, Carroll TJ, Self M, Oliver G, McMahon AP. 2008. Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. Cell Stem Cell 3(2) 169-181. 

The relatively large size of the tubular cells renders electrometric analysis simpler. The basal infoldings of the proximal tubular epithelium of Necturus do not obliterate the intracellular space as they do in this segment of the mammalian nephron. The absence of respiratory and pulsatile movements permits more stable cellular impalements. 

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