Quinidine Neostigmine

Angiotensin-converting enzyme inhibitors Cholinergics Bethanechol Neostigmine Cardiac agents Quinidine Digitalis Digoxin... 

Quinidine up to 970 mg daily Mild aggravation of myasthenic symptoms in one patient taking pyridostigmine and another taldr neostigmine. Development of myasthenic symptoms in 2 undiagnosed patients. 21-23... 

In these measurements, cyclic voltammograms were recorded after 5 min immersion of the Nafion-coated electrode into the sample solution containing a specific amount of a drug. Hexamethonium, acetylcholine and neostigmine equilibrated fairly rapidly and a near equilibrium state was obtained after 5 min of immersion. Only small changes in the voltammetric peak current were observed on subsequent scans. However, ca. 30 min was necessary to reach a near equilibrium state for quinidine. These differences in the equilibration time seems to be mainly dependent on the size of the cation. For analytical purposes it is not necessary to obtain an equilibrium response. The same measurements were carried out using a number of Nafion-coated GC electrodes. The results were quite reproducible and the variation of the relative peak current under different runs were within 5%. When the Nafion-coated GC electrode used for these measurements... 

---