Neosporin G.U. irrigant

Neomycin sulfate is available for topical and oral administration. Neomycin and polymyxin B have been used for irrigation of the bladder. For this purpose, 1 mL of a preparation (neosporin G. u. irrigant) containing 40 mg neomycin and 200,000 units polymyxin B per milliliter is diluted in 1 L of 0.9% NaCl solution and is used for continuous irrigation of the urinary bladder through appropriate catheter systems. The goal is to prevent bacteriuria and bacteremia associated with the use of indwelling catheters. 

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