Neoplastic drag

Kromhout H, Hoek F, Uitterhoeve R et al (2000) Postulating a dermal pathway for exposiue to anti-neoplastic drags among hospital workers. Applying a conceptual model to the results of three workplace sinveys. Ann Occup Hyg 44(7) 551-560... 

The antimetabolites interfere with various metabolic functions of cells, thereby disrupting normal cell functions. They inactivate enzymes or alter the structure of DNA, changing the DNA s ability to replicate These drag are most effective in the treatment of rapidly dividing neoplastic cells. Examples of the antimetabolites include methotrexate and fluorouracil (Adrucil). 

A recent report has shown that DNA hypomethylation may contribute to the induction of tumors in mice via an epigenetic mechanism causing chromosomal instability. In addition to facilitating neoplastic transformation, alterations in DNA methylation patterns have been shown to exert effects on embryonic development and acquired drag resistance to cytotoxic agents. Recent data from oiu laboratory have demonstrated the... 

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