Neomycin B-based Bilipids

Neomycin is an aminoglycoside antibiotic which acts as a polycationic amphiphile. It is used in topical creams, ointments, lotions, eye preparations and eardrops, and as an antibacterial preservative agent in some vaccines. Neomycin exhibits exceptional activity against Gram-negative bacteria and also has partial activity against Grampositive bacteria [72], 

The lipid bilayer is a thin polar membrane made of two layers of lipid molecules. These membranes are flat sheets that form a continuous barrier around the cell and thus acts as a good antibacterial agent. Derivatives of neomycin B are examples of bilipids [73, 74]. 

Bera and co-workers synthesised six polycationic amphiphiles with the backbone of neomycin B [75]. In their experiment, they converted all six amine groups on neomycin B to guanidine and all six compounds were tested against a panel of 

Loyola-Rodriguez, J.O. Garcia-Cortes, R.E. Martinez-Martinez, 

Patino-Marin, G.A. Martinez-Castanon, N.V. Zavala-Alonso and A. Amano, Australian Dental Journal, 2014, 59,4, 497. 

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