Neomycin aureus

In a leading cancer center in Houston, 24% of 758 Gram negative clinical isolates were resistant to tobramycin and 12% were resistant to amikacin (138). In 3144 bacterial isolates causing urinary tract infections in Chile, 74% were identified as Escherichia colv, 4.2% of these strains were resistant to gentamicin, and 1.3% were resistant to amikacin (139). In contrast, the resistance levels were 30% and 17% respectively, in the other enterobacterial strains. In Brazil, all isolates of methicillin-resistant S. aureus were also resistant to gentamicin, amikacin, kanamycin, neomycin, and tobramycin (140), and 97% of such strains from Spain were resistant to tobramycin (141). 

The sensitivity of the organisms to nitrofurantoin and five other antibiotics and chemotherapeutic agents was compared and, except for the greater sensitivity of Proteus to nalidixic acid, none of the test compounds surpassed the results achieved with nitrofurantoin. An interesting study by King proved that cultures of E. coli and Staph, aureus taken at the Cleveland Clinic in the U.S. between 1956 and 1961 showed increased sensitivity to nitrofurantoin but increased resistance to dihydrostreptomycin, chloramphenicol and neomycin. 

MRSA Methicillin-Resistant Staphylococcus aureus, ARP Antibiotic Resistance Profile AMC Amoxicillin-Clavulanic acid C-Chloramphenicol F Furazolidone Fc FlOTfenicol Gm Gentamycin N Neomycin NAL Nalidixic acid S Streptomycin Su Sulfonamides TFT Tetracycline TMP Trimetoprim AMP ampieillin PEN penicillin OXA oxacillin MET methicillin AXO ceftriaxone CIP ciprofloxacin LEVO levofloxacin GAT gatifloxacin ERY et34bromycin CLI clindamycin CL Cephalexin... 

Fig. 28. Inhibitory actions of neomycin on glutamic acid incorporation in Staph, aureus incubated with glucose and (1) glutamic acid only, (2) complete amino acid mixture. Cross-hatched area indicates growth-inhibitory range of concentration.

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