Neoglycoproteins preparation

The advancement in the techniques of the chemical synthesis of oligosaccharides and peptides (including molecular engineering) elevated the neoglycoprotein preparation to the de novo synthesis level, which opened a wide range of application possibilities. 

Figure 4 Principle of "click chemistry" applied to neoglycoprotein preparation.

Chen VJ, Wold F. Neoglycoproteins preparation of noncovalent glycoproteins through high-affinity protein- (glycosyl) ligand complexes. Biochemistry 1984 23 3306-3311. 

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