5-Neoglycoconjugates

Murata, T. and Usui, T. (2006) Enzymatic synthesis of oligosaccharides and neoglycoconjugates. Bioscience, Biotechnology, and Biochemistry, 70, 1049-1059. 

In an extensive and comprehensive survey, Chabre and Roy (Montreal) revisit the subject of neoglycoconjugates introduced three decades ago by Stowell and Lee in Volume 37 of this Series. It was then a nascent topic, and the Montreal authors now bring together in a single large article the vast new literature base that has... 

In this context, divalent presentation of this promising candidate has been investigated by the authors using the fixed cone conformation of calix[4]arene to allow introduction of the molecules onto the upper rim, and their projection into the same portion of space, thus mimicking, to some extent, a small portion of the natural cell-surface ganglioside. The synthesis of the divalent neoglycoconjugate was based on initial functionalization of the corresponding diacid with an aminated spacer and further introduction of squaric acid moieties. 

---