Nematode-cell division

Thiabendazole inhibits the helminlh-speciflc enzyme fu-maralc reductase. It is not known whether metal ions are involved or if the inhibition of the enzyme is related to thiabendazole s anthclmintie effeel. Benzimidazole anthelmin-tie drugs such as thiabendazole and mebendazole also aire.st nematode cell division in metaphase by interfering with microtubule assembly."- They exhibit a high affinity for tubulin, (he precursor protein for tnicrotiibulc synthesis. 

Currently, four benzimidazole compounds are in common use in equine practice fenbendazole, oxibendazole, mebendazole and oxfendazole. The benzimidazoles selectively bind to the nematode p-tubulin and inhibit the formation of microtubules, which are intracellular organelles with a variety of functions including the movement of both energy metabolites and chromosomes during cell division and the provision of the skeletal structure of the cell (Martin 1997). The benzimidazoles essentially starve the nematodes via intestinal cell disruption and inhibit worm egg production. From a clinical standpoint, the most important aspect of the mode of action of the... 

Mechanism of Action. The drug specifically blocks the glucose uptake by susceptible heliminths, thereby depleting the stored glycogen within the parasite. Obviously, the glycogen depletion invariably causes in an actual decreased generation of adenosine triphosphate (ATP), the latter is essentially needed for the survival and reproduction of the helminth. Besides, it inhibits cell-division in nematodes. ... 

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