Negishi protocol

Transition metal-catalyzed polymerizations have been reported to give high-purity, regioregular poly-3-alkylthio-phenes suitable for use in electronic devices. Thus, the Negishi protocol using a nickel catalyst and Rieke zinc was employed for the polymerization of 63 to produce the product as a low molecular weight polymer <2003CC2548>. 

E. Negishi, Overview of the Negishi Protocol with Zn, Al, Zr, and Related Metals, in Handbook of Organopalladiiun Chemistry for Organic Synthesis , ed. E. Negishi, John Wiley and Sons, Hoboken, NJ, 2002, p. 229. Editor. 

Since direct alkylation of a 2-lithioindole failed, a Negishi protocol was utilized to synthesize a 2-benzylindole, an intermediate for the novel CNS agent. 

III.2.1 Overview of the Negishi Protocol with Zn, Al, Zr, and Related Metals... 

B. VARIOUS OTHER FACTORS AND PARAMETERS FOR THE COMPARISON OF THE NEGISHI PROTOCOL WITH OTHER PROTOCOLS... 

On the basis of the Negishi protocol, C(sp)-C(sp) cross-couplings between alkynylzinc reagents and iodoalkynes have been developed as a mild and copper-free alternative to traditional protocols such as the Stephens-Castro or the Cadiot-Chodkiewicz [272]. 

Suzuki-Miyaura, Kumada-Corriu, and Negishi protocols for the construction of unusual heterobiaryl derivatives [59b]. 

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