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Negative design

Richardson, J. S., and Richardson, D. C. (2002). Natural beta-sheet proteins use negative design to avoid edge-to-edge aggregation. Proc. Natl. Acad. Sci. USA 99, 2754-2759. [Pg.95]

On this basis, coiled-coil designers often place oppositely charged residues Lys and Glu at complementary g and e sites to direct the assemblies that they are targeting (positive design), and make similar potential interactions in alternative structures repulsive (negative design). [Pg.91]

Figure 3 The widening of the energy gap between the native state and the misfolded structures during an increase in the environmental temperature. Positive design provides the lowering of the native state energy, whereas negative design contributes to the increase of the energy of misfolded structures. Figure 3 The widening of the energy gap between the native state and the misfolded structures during an increase in the environmental temperature. Positive design provides the lowering of the native state energy, whereas negative design contributes to the increase of the energy of misfolded structures.
Positive and Negative Design in Evolution and Thermal Adaptation of Natural Proteins... [Pg.2009]

Berezovsky IN, Zeldovich KB, Shakhnovich EL Positive and negative design in stability and thermal adaptation of natural proteins. PLoS. Comput. Biol. 2007 3 e52. [Pg.2012]

This phantom work was continued by Arnold et al. in a later publication [21]. This is a negatively designed study, used as an object lesson to warn the inexperienced user about the pitfalls of chemometrics. They... [Pg.120]


See other pages where Negative design is mentioned: [Pg.201]    [Pg.202]    [Pg.81]    [Pg.90]    [Pg.92]    [Pg.95]    [Pg.102]    [Pg.104]    [Pg.49]    [Pg.5540]    [Pg.5550]    [Pg.220]    [Pg.2008]    [Pg.2008]    [Pg.2009]    [Pg.2009]    [Pg.2010]    [Pg.73]    [Pg.76]    [Pg.194]    [Pg.145]    [Pg.171]    [Pg.419]    [Pg.5539]    [Pg.5549]    [Pg.44]    [Pg.1163]    [Pg.1163]    [Pg.100]    [Pg.39]    [Pg.44]    [Pg.629]    [Pg.630]    [Pg.639]    [Pg.926]    [Pg.84]    [Pg.2172]    [Pg.2172]    [Pg.240]   
See also in sourсe #XX -- [ Pg.220 ]




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