Needle-free device disposable

Fig. 2 The Intraject device. A prefilled, disposable, needle-free injector. (Courtesy of Aradigm Corporation, Hayward, California, U.S.A.)...

There are different devices conunerciaUy available for needle-free injectirai. Commonly jet injectors produce a high-velocity jet of medicine that penetrate the skin. Medicines and vaccines can be administered either intramuscularly or subcutaneously by means of a narrow, high velocity fluid jet that penetrates the skin. The gas-forced needle-free injection systems are typically made up of three components including an injection device, a disposable needle free syringe and a gas cartridge. 

The hi-dose delivery system for our intransal ketamine product candidate provides non-invasive (i.e. needle-free) administration compared to IV or IM injections, via a rugged, simple to use device that can be patient-administered if necessary. Each disposable device delivers a total of 30 mg ketamine with well-characterized, predictable pharmacokinetics. This approach to delivering subanesthetic doses of ketamine may be particularly advantageous in emergency situations where convenience, speed of drug delivery/onset, and avoidance of accidental needle sticks in healthcare providers are desirable. In addition, our intranasal ketamine product candidate was formulated to minimize neurotoxicity, a question that has been raised regarding the differently formulated ketamine product currently approved for anesthesia. 

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