Necrosis triggers

Irreversible renal insufficiency due to acute cortical necrosis triggered by severe renal hypoperfusion has been reported (SEDA-12, 86). A pharmacokinetic study showed that conversion of inactive R-ibuprofen to active 5-ibuprofen was greater in patients with renal impairment than in healthy controls this may aggravate renal insufficiency (21). 

T24.Dyhukt, J. M., Ankarcrona, M., Burkitt, M.,. Sjbholm,. 4.,. Strom, K., Orrenius, S., and Nico-tera, P. (1994). Different prooxidant levels stimulate grownh, trigger apoptosis, or produce necrosis of insulin-secreting RINm5F cells./. Biol. Chem. 269, 30553-30560. 

Acute over-activation of NHE1 results in a marked elevation in intracellular sodium concentration with a subsequent increase in intracellular calcium, via the Na +/Ca++ exchanger. This in turn triggers a cascade of injurious events that can culminate in tissue dysfunction and ultimately apoptosis and necrosis. This is commonly seen in organs such as the heart, brain and kidneys as a consequence of ischemia-reperfusion. 

Activated T cells begin releasing cytokines including interleukin-2 (IL-2), interferon-y, (IFN-y), tumor necrosis factor (TNF-a), and others.4,13 Cytokine activity leads to a rapid proliferation and turnover of skin cells, triggering the inflammatory process and the development of psoriatic skin lesions.4,13,14 TNF-a may have a role in disease severity it upregulates endothelial and keratinocyte expression of ICAM-1,... 

There are few cell death triggers that are only capable of inducing either apoptosis or necrosis 614... 

Calcium ion release from the ER and the accumulation of misfolded proteins in the ER can trigger necrosis, and... 

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